Methotrexate: a guide for Young People

Methotrexate is a drug used to treat Crohn’s Disease and occasionally Ulcerative Colitis – the two main forms of Inflammatory Bowel Disease (IBD). You may be given methotrexate if you keep getting flare-ups even though you are taking other medicines for your Crohn's or Colitis. Methotrexate may also be able to help you cut down or come off steroids. For some people, methotrexate is a good alternative to azathioprine and mercaptopurine.

You may be given methotrexate if you keep getting flare-ups even though you are taking other medicines for your Crohn's Disease or Ulcerative Colitis. Methotrexate may also be able to help you cut down or come off steroids. For some people, methotrexate is a good alternative to azathioprine and mercaptopurine. Methotrexate can also be used in combination with biological drugs, such as infliximab or adalimumab.

What does it do?
What does it look like?
How often do I take it?
Will I feel better staright away?
Why do I need to take folic acid as well?
I've been told I need tests before and while I take methotrexate. Why is that?
Will I get side effects?
7 things you can do to help keep yourself healthy while taking methotrexate
What else should I know about methotrexate?
Where can I get more information if I am worried?
Help and support from Crohn's & Colitis UK
How we write our information

Last reviewed: March 2016