Crohn's research gets £1.8m funding boost

Dr Gwo-tzer Ho and his team at University of Edinburgh have received £1.8 million in funding to further their research into how mitochondria (tiny part of our cells that are key to providing our bodies with energy) could have an impact on Crohn’s Disease.

This began with an £8,000 project grant from Crohn’s & Colitis UK in 2016, and we’re now funding a follow-on project.

In both Crohn’s Disease and Ulcerative Colitis, mitochondria have been found to give off ‘danger signals’ that immune cells confuse with bacteria, leading them to trigger an unintended and harmful inflammatory responses.

The project aims to find out if these danger signals could be used to develop a simple, non-invasive blood or stool test, to show if there’s inflammation in the gut. At the moment, people with the conditions have to undergo a colonoscopy for doctors to see this.

The researchers will investigate if this test could allow doctors to predict what people’s Crohn’s might look like in the future, which could lead to new treatments. It could also help doctors spot different forms of Crohn’s and develop personalised treatments.

Funding comes from The Leona M. and Harry B. Helmsley Charitable Trust, a US-based charity committed to improving lives.

Helmsley’s Crohn’s Disease Program aims to find a cure for the condition and to enhance peoples’ quality of life.

We are only able to fund research thanks to our generous donors and amazing fundraisers. Thank you so much for your support.