UK's first predictive test for Crohn's and Colitis

Scientists at the University of Cambridge have developed a new test that can reliably predict the future course of Crohn’s Disease or Ulcerative Colitis, transforming treatments for people with the conditions and paving the way for a personalised approach.

In the latest study, published in the journal Gut, researchers at the Department of Medicine, University of Cambridge, worked with 69 people with Crohn’s to see whether it was possible to develop a useful, scaleable test by looking at whole blood samples alongside CD8 T-cells and using widely-available technology.

The team used a combination of machine learning and a whole blood assay known as qPCR – a relatively simple tool used in NHS labs across the country – to identify genetic signatures that were the same as the two groups (mild and severe) from their previous study.

The researchers then validated their findings in 123 people with Crohn’s or Colitis recruited from clinics in Cambridge, Nottingham, Exeter and London.

The accuracy of the test is comparable to similar biomarkers used in cancer, which have helped transform treatment.

They found the new test was 90-100% accurate in correctly identifying people who did not require multiple treatments.

The test is now being developed further by PredictImmune and has led to the creation of PredictSURE IBD™. 

It is a simple blood test which can provide valuable information to doctors about the expected way people’s condition will affect their bodies. 

The team is also involved in a £4.2 million trial to see whether using the biomarker to guide treatment at the time of diagnosis can lead to better outcomes for people with Crohn’s or Colitis.