Methotrexate

This information answers common questions about methotrexate as a treatment for Crohn’s Disease and Ulcerative Colitis (the two main forms of Inflammatory Bowel Disease - IBD). It is about methotrexate in general and is not intended to replace specific advice from your doctor or any other health professional. 

This information is about methotrexate in general and is not intended to replace specific advice from your doctor or any other health professional. 

For further information, please talk to your doctor or specialist IBD team, or look at the information sheet supplied with your medication or on the website: medicines.org.uk

Other names for this medicine
Why am I being treated with this medicine?
How does it work?
How long will it take to work?
How long will I be taking methotrexate?
When and how do I take methotrexate?
What is the normal dosage?
Why have I also been prescribed folic acid?
How effective and safe is methotrexate?
Will I need any special checks before i start taking methotrexate?
Will I need ongoing checks while I am taking methotrexate?
Will I need to take any special precautions while on methotrexate?
Can I take other medicinces along with methotrexate?
Can I have immunisation while on methotrexate?
Can I drink alcohol while on methotrexate?
Does Methotrexate affect fertility and pregnancy?
What about breastfeeding?
What are the possible side effects of methotrexate?
Who should I talk to if I am worried?
Help and support from Crohn's & Colitis UK
How we write our information

Last reviewed: January 2019